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Pathophysiology of Hypertension
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Hypertension Pathophysiology
The understanding of the pathophysiology of hypertension is critical to developing effective therapies to reducing high blood pressure. The pathophysiology of hypertension is complex and not very well understood. There is some evidence that supports a hypothesis that the primary fault in the pathophysiology of hypertension is a defect in the calcium binding of the plasma membrane of the cells of a pressure-regulating center in the nervous system. Because the pathophysiology of hypertension consists of many factors, a well-designed combination of regiments is believed to be the best plan of attacked in treating the problem. Therefore, targeted complementary blood pressure lowering strategies provide the most effective approach to achieving blood pressure lowering goals.
Fluid
Fluid restriction may increase the risk for calcium phosphate precipitation in the tubules and may contribute to a progression of kidney disease. Therefore, intake of fluids should be encouraged and intake of sodium should be restricted only to the relatively high sodium content that is included in products that are geared to aid patients to quit smoking.
Smoking has been found to be an independent risk factors for development of kidney failure. Especially, in men who have been diagnosed with kidney disease.
Calcium
Calcium compounds may be used to bind phosphates and are often used in the treatment of hypertension. This treatment provides a safe, often effective and relatively inexpensive means to controlling the problem.
Stress
Stress, certainly, plays a major role in hypertension. It is thought to be the influential factor in the development of high blood pressure, right behind obesity. In the case of stress, the blood pressure is often increased during times of stress and returns to normal when the cause of the stress is removed. However, constant stress can cause a situation where high blood pressure will need to be treated with medication.
Obesity
Much the same can be said with obesity. High blood pressure may be brought on by weight gain but may, also, return to normal when the weight is lost. However, once again weight gain can bring about a situation where medication is needed to control the high blood pressure.
Treatment
Treatment of hypertension has largely consisted of the administration of antihypertensive medications. Despite the large number of drugs available in various pharmacological categories, including diuretics, alpha-adrenergic antagonists, beta-adrenergic antagonists, calcium channel blockers, angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor antagonists, the need for an effective treatment of hypertension is still not satisfied.
Conclusion
It is not always possible to avoid hypertension but in many cases it is. In these cases, the treatment is prevention. Weight control, healthy eating, exercise and the avoidance of alcohol abuse are the prescription to avoiding high blood pressure in most young and middle-aged people. This, alone, could help save many people from complications in the future.
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Pathophysiology of Hypertension
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